IMGT Web resources: IMGT repertoire

Alignment of alleles: Atlantic cod (Gadus morhua) IGHV3S18

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 T   Q   Q   L   T   Q   P   E   S       L   I   V   R   P   G   Q   S   L   N
  X76508  ,IGHV3S18*01, 101-14  ACA CAA CAG CTT ACT CAG CCA GAG TCT ... CTG ATT GTC CGA CCT GGT CAA TCT CTG AAC
                                 C   E  
  AJ279382,IGHV3S18*02, 109     TGT G-- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- ---

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 I   R   C   Q   V   S   Y   S   V   S   S   Y   Y                       T   Q
  X76508  ,IGHV3S18*01, 101-14  ATC CGC TGT CAG GTC TCT TAT TCT GTT AGT AGC TAC TAC ... ... ... ... ... ACG CAA

  AJ279382,IGHV3S18*02, 109     --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   D   G   N   P   L   E   W   I   G   Y   I   R   A   D   G
  X76508  ,IGHV3S18*01, 101-14  TGG ATA AGA CAA CCT GAT GGA AAC CCA CTG GAA TGG ATT GGT TAT ATT CGT GCC GAT GGC
                                                                                                     T  
  AJ279382,IGHV3S18*02, 109     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- A-- --- ---

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 K                   K   V   K   D   S   L   S       S   K   F   S   L   A   V
  X76508  ,IGHV3S18*01, 101-14  AAA ... ... ... ... AAA GTG AAA GAC TCC CTT AGT ... AGT AAA TTC AGT CTT GCC GTT

  AJ279382,IGHV3S18*02, 109     --- ... ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---


                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   E   A   S   K   T   V   T   L   Q   G   Q   N   M   Q   P   G   D   S   A
  X76508  ,IGHV3S18*01, 101-14  GAC GAG GCC AGT AAA ACA GTA ACT TTG CAA GGC CAA AAC ATG CAG CCT GGA GAC TCA GCT

  AJ279382,IGHV3S18*02, 109     --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 V   Y   Y   C   A   R
  X76508  ,IGHV3S18*01, 101-14  GTG TAT TAT TGT GCC AGA     #c

  AJ279382,IGHV3S18*02, 109     --- --- --- --- --- ---     #c

#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc